Lymphocyte Immunotherapy is Not Necessary for Primary Unexplained Abortions
نویسنده
چکیده
Recurrent Pregnancy Loss (RPL) is a disease, defined by two or more failed pregnancies, affecting about 5% pregnant women. RPL can be classified into primary RPL and secondary RPL [2]. Primary RPL aborters are those who have lost all previous pregnancies and have no live birth. Secondary RPL aborters are those who have at least one successful pregnancy, irrespective of the number of pregnancy losses. In 50% to 75% of couples with recurrent pregnancy losses, the etiology is Unknown (URPL), although genetic/chromosomal causes, hormonal abnormalities, metabolic abnormalities, uterine abnormalities, anti-phospholipid syndrome, thrombophilias, male factor have been implicated. URPL is considered to be a model of immunological rejection of the fetus by the mother [3-5].
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High anti-paternal cytotoxic T-lymphocyte precursor frequencies in women with unexplained recurrent spontaneous abortions.
A number of cases of unexplained (idiopathic) recurrent spontaneous abortions may be attributable to immunological mechanisms. Several lines of evidence indicate that some immunocompetent effector cell populations play an important role in the pathogenesis of unexplained miscarriages. However a suitable method is lacking for defining an existing immunological background of recurrent spontaneous...
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